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Bacteria-Human Somatic Cell Lateral Gene Transfer Is Enriched in Cancer Samples

Figure 4

Relative proportion of OTUs in the microbiome compared to the proportion in bacterial DNA integration.

The relative contribution of an OTU at the family level is shown (Panel A) for the microbiome (blue) and bacterial integrations (purple). OTUs that are over-represented in the microbiome include several common lab contaminants that were observed at low levels across multiple samples and centers (e.g. P. acnes). OTUs that are over-represented in the bacterial integrations are more likely to be the organisms mutagenizing the human somatic genome. The contribution of λ phage microbiome (blue) and integrations (red) was measured and illustrated separately (Panel B).

Figure 4