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The Ability of Flux Balance Analysis to Predict Evolution of Central Metabolism Scales with the Initial Distance to the Optimum

Figure 3

Measures of optimality and predictability after adaptation of LTEE populations to glucose for 50,000 generations.

A,D) The % optimality of the ancestor (black) and evolved isolates (grey, same order as Fig. 2); B,E) distance to optimal flux distribution (plotted as log(DEO/DAO)); and C, F) comparison of predicted to observed flux ratios for FBA-predictions based upon BM/S (A–C) or ATP/S (D–F). Error bars represent standard errors of three biological replicates.

Figure 3