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An Integrated Computational/Experimental Model of Lymphoma Growth

Figure 2

Algorithm flowchart.

Refer to Materials and Methods and Text S1 for equations. Using the cellular-scale data, we measured values for proliferation and apoptosis for both drug-sensitive and drug-resistant tumors and calculated corresponding values for the model mitosis and apoptosis parameters λM and λA. We solved Eq. (2) for the local levels of cell substrates n at each time step of simulation of tumor growth. The parameters were input into Eq. (3) to numerically calculate the source mass terms Si, which were then used in Eq. (1) to compute the volume fractions of viable ρV and ρD dead tissue. These fractions were used in Eq. (4) to obtain the tumor tissue growth velocity.

Figure 2