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Substrate-Specific Reorganization of the Conformational Ensemble of CSK Implicates Novel Modes of Kinase Function

Figure 4

Theoretical scattering curves of the best-fitting conformational ensembles fitted to the experimental scattering curves (black) for apo Csk (A, orange), AMP-PNP bound Csk (B, red), and ADP-bound Csk (C, blue).

The χ2 value for the ensemble fit to the experimental data appears in the lower left corner of the plot for each curve. A comparison of the fit of the apo Csk ensemble (orange) and the ADP-bound ensemble (blue) to the ADP experimental data (black) appears in D.

Figure 4