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Substrate-Specific Reorganization of the Conformational Ensemble of CSK Implicates Novel Modes of Kinase Function

Figure 2

The probability of Rg (P(Rg)) of the 5% of conformations with the lowest χ2 values from the SBM simulations.

Apo Csk appears in black, AMP-PNP bound Csk appears in red, and ADP bound Csk appears in blue. The three most prominent populations, from which representative conformations were selected for ensemble analysis, are highlighted for each state.

Figure 2