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Interplay of Gene Expression Noise and Ultrasensitive Dynamics Affects Bacterial Operon Organization

Figure 5

Dependence on expression level for frequencies of gene pairs of physically interacting proteins sharing operons.

A dataset of single-cell protein and mRNA copy numbers in E. coli [43] shows reduced frequency of coupling for abundant proteins (A) and mRNA (B). Error bars represent one standard deviation from bootstrapping the data 1,000 times. Significance levels were determined by a bootstrap test.

Figure 5