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Interplay of Gene Expression Noise and Ultrasensitive Dynamics Affects Bacterial Operon Organization

Figure 1

Types of coupling in protein production affect correlations in their fluctuations.

A. Two proteins (A and B) can have coupled translation (1), coupled transcription with independent translation events (2), or uncoupled transcription (3). B, C. Scatter plots showing predicted single-cell distributions of copy numbers for proteins A and B with different coupling as indicated in models without (panel B) or with (panel C) transcriptional bursting. For simplicity, these models do not include extrinsic noise.

Figure 1