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Rational Engineering of Enzyme Allosteric Regulation through Sequence Evolution Analysis

Figure 2

Amino acid compositions of catalytic and allosteric residues.

The fraction of each amino acid of catalytic and allosteric residues is shown. Allosteric sites have more hydrophobic residues compared to catalytic sites, while catalytic sites have more charged amino acids than do allosteric sites. The statistical significance (P-value) was measured by Fisher's exact test; *P<0.05 and **P<0.005.

Figure 2