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The Generation of Phase Differences and Frequency Changes in a Network Model of Inferior Olive Subthreshold Oscillations

Figure 3

Robust modulation of network frequency by changing the inter-cluster coupling strengths.

A: Membrane potential of one neuron per cluster just before and after manually changing the inter-cluster connection strength in the reference network. The change in inter-cluster strength caused a shift in the synchronized oscillation frequency from 6.3 Hz to 10.9 Hz. B: Short-term Fourier transformation of the membrane potential of one neuron in the network indicates the shift in frequency. C: Fourier transformation of the membrane potential of one neuron of each cluster. All clusters oscillate at the same frequency and are subject to the same shift. D: Histogram of frequencies at which the same network with pseudo-random inter-cluster connections strengths can oscillate in synchrony. Only changing the inter-cluster coupling strength (within realistic ranges, i.e., CC<20%) can be sufficient to bring the network to a state of synchronized oscillations with frequencies between 6 and 11 Hz.

Figure 3