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Computing with Neural Synchrony

Figure 1

Synchrony receptive field.

A, When neuron A is hyperpolarized by an inhibitory input (top), its low-voltage-activated K channels slowly close (bottom), which makes the neuron fire when inhibition is released (neuron models are used in this and other figures). B, Spike latency is negatively correlated with the duration of inhibition (black line). Neuron B has similar properties but different values for the threshold and K channel parameters (blue line). The synchrony receptive field of neurons A and B is the stimulus with duration 500 ms. C, A postsynaptic neuron receives inputs from A and B. D, It is more likely to fire when the stimulus in the synchrony receptive field of A and B. E, Distribution p(v) of the postsynaptic membrane potential when the neuron is not stimulated (left, “background”) and when it receives an input of size Δv (right, “signal”; e.g. neurons A and B shown in panel C fire together). The standard deviation of the distribution is σ. The neuron fires when v is greater than the spike threshold θ. F, Receiver-operation characteristic (ROC) for three levels of noise, obtained by varying the threshold θ (black curves). The hit rate is the probability that the neuron fires within one integration time constant τ when depolarized by Δv, and the false alarm rate is the firing probability without depolarization. The corresponding theoretical curves, with sensitivity index d′ = Δv/σ, are shown in red. G, When a neuron receives two synchronous inputs of size w (PSP peak), the peak potential is 2w plus the background noise (left). When the second input arrives after a delay δ, the peak is plus the background noise (right). H, Distinguishing between synchronous inputs and delayed inputs corresponds to setting a threshold θ between two distributions separated by .

Figure 1