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Near-Native Protein Loop Sampling Using Nonparametric Density Estimation Accommodating Sparcity

Figure 8

Loop sampling comparison.

Boxplots display the RMSD sampling distribution of the DPM-HMM method alongside that of the LoopyMod method for loops of different difficulty: canonical (CDRH1) and non-canonical (CDRH3) loops. Comparison of sampling to the canonical CDRH1 is shown by the left 2 boxplots and the comparison to the non-canonical CDRH3 by the right 2 boxplots. In both cases, the DPM-HMM exhibits a tighter distribution and lower median RMSD.

Figure 8