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Binding Leverage as a Molecular Basis for Allosteric Regulation

Figure 6

Analysis of threonine synthase (ThrS) using LLF10.

(A) Cartoon of structure with the coenzyme PLP drawn with white spheres and the SAM molecules with grey spheres. Protein coordinates are taken from PDB entry 1e5x and ligand coordinates from 2c2b. (B) Rotated view showing the SAM binding site, colored according to fi(0.42). (C) Same view as (A) showing fi(0.42) for active site cleft. (D) ROC curves.

Figure 6