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Binding Leverage as a Molecular Basis for Allosteric Regulation

Figure 5

Analysis of protein kinase A (PKA) using LLF10.

(A) Cartoon of protein structure. Protein coordinates are taken from PDB entry 1j3h and ligand coordinates from 1atp. (B) Residues colored by fi(0.04), with cyan representing fi = 0 and magenta the highest recorded fi. (C) ROC curves obtained with the four measures in Table 1.

Figure 5