Binding Leverage as a Molecular Basis for Allosteric Regulation
(A) Illustration of binding leverage for one normal mode. The outline represents the protein surface and the grey dumbbells ligands. The curved arrow shows the general direction of motion in one normal mode and the small arrows the direction of motion for specific Ca atoms in the same mode. Dashed lines indicate pairs of atoms whose interconnecting line crosses the ligand. (B) Illustration of the residue count fi(x) for three probe locations.