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deFuse: An Algorithm for Gene Fusion Discovery in Tumor RNA-Seq Data

Figure 7

Fusions in sarcoma samples.

a) Read depth across HNF1A exonic positions shows that only the region after the fusion boundary is being expressed, evidence of the possible biallelic inactivation of HNF1A. b) Putative RREB1-TFE3 chimeric protein showing preservation of TFE3's basic helix-loop-helix (bHLH) leucine zipper (LZ) domain and N-terminal activation domain (ATA), in addition to 4 of RREB1's zinc finger (ZF) motifs.

Figure 7