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Stochastic Ion Channel Gating in Dendritic Neurons: Morphology Dependence and Probabilistic Synaptic Activation of Dendritic Spikes

Figure 7

Channel kinetics determine the functional impact of stochastic gating.

(A–B) Simulated membrane potential of a model layer V pyramidal neuron (A) and a dentate gyrus granule cell (B) containing either a deterministic leak conductance, fast gating stochastic leak channels or slow gating stochastic leak channels. (C–D) Mean variance of membrane potential fluctuations, recorded from simulated layer V pyramidal neurons (C) and simulated dentate gyrus granule cells (D), plotted as a function of distance from the cell body.

Figure 7