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Transat—A Method for Detecting the Conserved Helices of Functional RNA Structures, Including Transient, Pseudo-Knotted and Alternative Structures

Figure 12

Known RNA secondary structure and Transat predictions for telomerase RNA for vertebrates (left, RF00024) and ciliates (right, RF00025) for a p-value threshold of .

The Transat predictions indicate that the co-transcriptional folding of the vertebrate sequences may involve large-range structural rearrangements, whereas the two hair-pins of the known ciliate structure are predicted to form independently. Note that Transat correctly captures the known pseudo-knotted structure of the vertebrate telomerase RNA (left). See the text or the caption of Figure 9 for more information on arc-plots.

Figure 12

doi: https://doi.org/10.1371/journal.pcbi.1000823.g012