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A Human-Specific De Novo Protein-Coding Gene Associated with Human Brain Functions

Figure 3

Alignment of human FLJ33706 ORF with orthologous genomic sequences in four other primates.

For each position in human FLJ33706 ORF, the corresponding orthologous genomic sequences in chimpanzee, gorilla, orangutan and rhesus monkey were aligned to human reference to identify the types of variations. Only amino acid sites with at least one variation among “Human-Human” (SNP), “Human-Chimpanzee”, “Human-Gorilla”, “Human-Orangutan” or “Human-Rhesus” were shown. Identical sites were shown as black dots while divergent sites were shown in red (non-synonymous mutations), green (synonymous mutations) and blue (SNP). Two human-specific mutations that escaped stop codons were highlighted by black frames. Amino acids with non-synonymous variations were highlighted in red while synonymous variations in blue. All sequencing data in this study were traced and manually checked to ensure reliability.

Figure 3