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Identifying Changes in Selective Constraints: Host Shifts in Influenza

Figure 3

Changing equilibrium frequencies and rates versus selective constraints.

Top: Dependence of rate scaling factor ν (solid line) and rate of substitutions for adaptive (positive) selection Γ+ (dotted line) and purifying (negative) selection Γ (dashed line), scaled by mutation rate μ, as a function of scaled selective disadvantage of residue B compared with residue A (2Neff s). Bottom: Equilibrium frequencies πA of A (solid line) and πB of B (dashed line) as a function of scaled selective disadvantage.

Figure 3