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Identifying Changes in Selective Constraints: Host Shifts in Influenza

Figure 1

Possible evolutionary scenarios.

Two possible phylogenetic trees representing the situation where eight different avian sequences have a L in a given position, while eight different human sequences have a V. (Branch lengths are not drawn to scale.) The situation shown on the right provides much weaker evidence for a shift in selective constraints compared with the situation shown on the left.

Figure 1