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Probing the Flexibility of Large Conformational Changes in Protein Structures through Local Perturbations

Figure 6

RIP perturbations of Dihydrofolate Reductase (DHFR).

(A) RIP deformation map. (B) Structural linchpins and perturbation strength histogram. (C) Local flexibility mapped on structure and in histogram. Colors are as in Figure 4.

Figure 6

doi: https://doi.org/10.1371/journal.pcbi.1000343.g006