Sequence Similarity Network Reveals Common Ancestry of Multidomain Proteins
Figure 2
Domain models of a pair of multidomain homologs and a pair of sequences with a domain-only match.
(A) Domain architectures of the multidomain homologs PDGFRB and PRKG1B. These sequences share a Pkinase domain, but have different auxiliary domains. (B) Domain architectures of PDGFRB and NCAM2, which have significant sequence similarity due to shared Ig domains, but do not share common ancestry.