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Decoupling between activation time and steady-state level in input-output responses
Fig 6
Sensitivity of decoupling via the rate scale separation (A–C) and incoherent regulation (D–I) mechanisms to single-parameter perturbations.
(A) The best parameter set, 
, obtained from the optimization in Fig 3A–E (see also Fig 3E, green line). (B–C) Distributions of 
(B) and 
(C) arising from perturbations in each parameter, starting from the choice of 
in A. The colormap represents the log-ratio of the perturbed parameter value, 
, with respect to the optimal parameter value, 
. (D) The best parameter set, 
, obtained from the optimization in Fig 4 (see also Fig 4D, green line). (E–F) Distributions of 
(E) and 
(F) arising from perturbations in each parameter, starting from the choice of 
in D. (G) A modified version of the parameter set in D, in which all horizontal rates have been set to the same value, 
, as described in the text. (H–I) Distributions of 
(H) and 
(I) arising from perturbations in each parameter, starting from the choice of 
in G. Here, the horizontal rates were perturbed as a single parameter, ℓ, as described in the text.
doi: https://doi.org/10.1371/journal.pcbi.1014288.g006