Thrombin activity confinement and dense granule release drive the dynamics of arterial thrombus
Fig 4
Comparison between the continuum model simulations and in vivo experiments on laser-induced thrombosis in mice with Hermansky-Pudlak syndrome.
A) Temporal dynamics of thrombus core area and total thrombus area in vivo (light ear mouse, data from Movie D from [20], orange and red dots) and in the model simulation (green and blue dots). B) Upper image: image of a thrombus in the model simulation for HPS mouse at 130 s (vessel lumen is brown, shell is blue, core is dark blue). Flow direction was from top to the bottom. Color bar shows the values of porosity corresponding to colors on this image. Lower image: profile of thrombin in the model simulation for HPS mouse at 130 s. Color bar shows values of thrombin concentration (units [nM]) corresponding to colors on this image. Note the significant decrease of overall thrombus size and thrombus core size in HPS mouse compared to the wild type mouse. C) Overall data on temporal dynamics of thrombus core area and thrombus area in vivo (wild type mouse and mouse with Hermansky-Pudlak syndrome denoted as WT and HPS; data from Movie A (orange and red dots) and Movie D (light magenta and robin egg blue dots) from [20]; and in the model simulations (green and dark blue dots for WT mice; dark purple and dark olive dots for HPS mice).