Thrombin activity confinement and dense granule release drive the dynamics of arterial thrombus
Fig 3
Continuum model profiles of thrombin and ADP, dense granule density and platelet activation state.
On A)-D) color bar shows the values of concentration (units [nM]) corresponding to colors on this image. A), B)-Profiles of thrombin at 60 s and 130 s. C), D) - Profiles of ADP at 60 s and 130 s. Note the significant drop of ADP concentration in thrombus at 130 seconds. E), F)- Profiles of dense granule density inside the thrombus at 60 s and 130 s. Color bar shows the values of dense granule density (arbitrary units) corresponding to colors on the image. G), H)- Profiles of platelet activation state at 60 s and 130 s. Platelets reversibly activated by ADP are shown in green, platelets irreversibly activated by thrombin are shown in brown, vessel lumen is blue. Note the depletion of dense granules in a thrombus core at 130 s.