Putting BASIL in a BLT: A Bayesian filtering method for estimating the fitness effects of nascent adaptive mutations
Fig 6
The effects of down-sampling on BASIL and FitMut2 performance.
We reanalyzed the Levy 2015 dataset (Replicate 1) using BASIL and FitMut2 after reducing sequencing coverage or sampling frequency. See Materials and Methods for details. A. Mean fitness trajectories inferred by BASIL on full and reduced data. B. Inferred selection coefficients for lineages identified as adapted by BASIL in both full and reduced datasets. The 1-to-1 line is shown in light gray. C. Distribution of fitness effects of lineages identified as adapted by BASIL in full and reduced data. Inset shows the tail of the distribution. D–F. Same as A–C but for FitMut2. G–L. Same as A–F but for reduced sampling.