Individual trajectories for recovery of neocortical activity in disorders of consciousness
Fig 2
Estimating corticothalamic model parameters in DoC.
Panel A shows the group-averaged empirical power spectra and model-estimated power spectra for the different groups alongside the goodness of fit of the estimation for the different groups. Panel B presents a graphical representation of the model parameters and their estimates across the different groups. Blue circles in the UWS group denote MCS* patients. Both excitatory and inhibitory corticothalamic synaptic strengths differ between MCS and UWS. Panel C illustrates the results of our classification analysis of MCS vs. UWS, showing the feature importance for each parameter (left), the receiver operating characteristic (ROC) curve (middle), and the surrogate distribution of AUC values (right). The genuine AUC value is depicted in green. The features that remained in the final model are depicted in pink (left panel), with corticothalamic excitatory GESE being the feature or parameter that contributes most strongly to the classification. Abbreviations: healthy controls (HC), minimal conscious state (MCS), unresponsive wakefulness syndrome (UWS), excitatory corticothalamic synaptic strengths (GESE), inhibitory corticothalamic synaptic strengths (GESRE), Excitatory cortical synaptic strengths (GEE), inhibitory cortical synaptic strengths (GEI), intrathalamic synaptic strengths (GSRS), synaptic decay and rise constants (α and β), corticothalamic time delay (t0). (FDR corrected).