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Blood flow in the human cerebral cortex: Large-scale pial vascularization and 1D simulation

Fig 5

Pial vascular network built with the proposed multi-stage approach.

Top panel: Orthogonal projections on transverse, coronal and sagittal planes, and ventro-lateral perspective, with color-code given by vessel diameter in . Mid panel: Multi-staged vascularization of the pial space. From left to right: initial sub-networks from the ADAN model (totaling 450 vessel segments), first and second sequential vascularization stages with different cost functions (totaling 8 390 and 40 390 vessel segments, respectively), and third vascularization stage after merging the parallelized sub-domain networks (totaling 234 344 vessel segments). Bottom panel: Distribution of vessel diameters D, vessel lengths L, and their joint kernel density estimate distribution in the pial networks for each of the three territories, (red), (green), and (blue), and also for the entire pial network (gray). All distributions are in logarithmic scale.

doi: https://doi.org/10.1371/journal.pcbi.1013459.g005