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A coupling model of transcranial magnetic stimulation induced electric fields to neural state variables

Fig 6

Synaptic inputs and model output of a single example synapto-dendritic delay simulation.

(, , , V/m, 0.01 ms step size simulated for 50 ms). (A) Inhibitory axonal delay kernel (L2/3 BC population). (B) Excitatory axonal delay kernel (L2/3 PC population). Overlaid over both kernels is the postsynaptic L5 PC with soma at -1584 , an example dendritic compartment marked by a green cross, and the bin containing that compartment boxed in red. (C) Zoomed-in view of L5 PC morphology near the green cross. (D) Partial integral of the inhibitory axonal delay kernel across the red boxed, 50 bin in (A). (E) Partial integral of the excitatory axonal delay kernel across the red boxed, 50 bin in (B). (F) Double exponential conductance kernels describing AMPA, NMDA, GABAa, GABAb synapses. (G) Synaptic conductance of each synapse type at green cross-marked compartment, computed by the weighted convolution of (D) and (E) with the kernels in (F). (H) Simulated trans-membrane current of each conductance-based synapse at green cross-marked compartment. Positive valued current flows into the cell. (I) Dendritic current flowing into the L5 PC soma from the dendrites due to synaptic inputs.

doi: https://doi.org/10.1371/journal.pcbi.1013413.g006