Live and let die: Lysis time variability and resource limitation shape lytic bacteriophage fitness
Fig 6
a. Plaque expansion experiment schematic. b. Results of plaque expansion competition experiment, in which a wild type phage with lysis time mean 17 min, std 2.5 min competes against a mutant with varied lysis time mean (y-axis) and std (x-axis). i. Difference in numerically predicted growth rate, using Eq 3. ii. Mutant fixation probability in stochastic simulation. iii. Fitness difference in stochastic simulation. iv. Infection front velocity. Note that in the first and third rows, the visual scale has been set to saturate at . Axes are scaled such that each pixel step in the y direction corresponds to a 1 minute change in mean lysis time, while each pixel step in the x direction corresponds to an equivalent fractional change in lysis time std versus the wild type value: 2.5/17 minutes. The four-point star on all panels corresponds to the point in parameter space at which both phages have exactly the same parameters. The white polygons in rows ii and iv outline the parameter space in which the wild type reaches fixation.