Proteostasis signatures in human diseases
Fig 2
Proteostasis profiles of diseases.
For each of the 32 diseases included in this study, we computed the fraction of proteostasis proteins within each disease gene set (brown bars). Across the 32 diseases, the fraction of proteostasis proteins within disease gene sets ranged from 20% to 36%. We further decomposed disease genes involved in proteostasis into their relevant proteostasis pathways and functional classes. This was done by identifying which pathway/functional class was over-represented within the proteostasis proteins corresponding to the genes of each disease gene set. The statistical significance of over-representation of a pathway or functional class was determined using the hypergeometric test (p-value < 0.01, represented as a coloured dot) and represented as a spot within the figure. Colour-coding of the spots reflect their involvement in the autophagy-lysosome pathway (brown), the ubiquitin-proteasome system (green) and the anabolic system (blue).