Mycobacterium susceptibility to ivermectin by inhibition of eccD3, an ESX-3 secretion system component.
Fig 3
M. tuberculosis ESX-3 EccD3 domain.
(a) EccD3 N-terminal and EccD3 C-terminal interactions with the nine drugs having Z-score values less than -1. D, Molecular interactions between EccD3 interface residues and (b) selamectin, (c) moxidectin, and (d) rifalazil in 2D diagram. Ligplot was used for 2D map.