Tumor-immune partitioning and clustering algorithm for identifying tumor-immune cell spatial interaction signatures within the tumor microenvironment
Fig 6
TIPC application on three different immune cell types, namely (a-c) cytotoxic memory T cells, (d-f) eosinophils, and (g-i) neutrophils in CRC (NHS/ HPFS).
(a,d,g) Heat maps display the distinct immune cell organization of the resulting TIPC subtypes which demonstrate (b,e,h) variable but overlapping immune cell densities. (c,f,i) Kaplan-Meier and log-rank test show that these TIPC spatial subtypes were significantly associated with CRC-specific survival (see S3 Fig for the corresponding risk tables). Abbreviations, CSR = cold, stroma-rich, CTR = cold, tumor-rich, HD = hot and disperse, HTCC = hot, tumor-centric clustering, HSCC = hot, stroma-centric clustering, HC = hot and clustered, HCTR = hot and clustered, tumor-rich, HCSR = hot and clustered, stroma-rich.