Antiviral capacity of the early CD8 T-cell response is predictive of natural control of SIV infection: Learning in vivo dynamics using ex vivo data
Fig 2
Model fits longitudinal in vivo virological and ex vivo suppressive capacity data.
Model predictions (lines) from simultaneous fitting of the best-fit model (Methods) to all the three datasets (symbols), namely, viremia (left panels), SIV DNA (middle panels) and suppressive capacity (right panels). Macaques highlighted in red were progressors while those in black were controllers. The dashed line in the left panels indicates 400 copies mL-1. Open symbols are below the limit of detection. The predictions for the remaining 12 macaques are presented in S10 Fig. The resulting population parameter estimates are in Table 1 and individual parameter estimates are in S10 Table.