Multi-scale modelling of location- and frequency-dependent synaptic plasticity induced by repetitive magnetic stimulation in the dendrites of pyramidal neurons
Fig 5
Pharmacology in silico: rMS-induced LTP depends on dendritic sodium and calcium through voltage-gated calcium channels, as well as synaptic NMDA channels.
(a): Schematic of electric field for all panels in this figure. Electric field vector direction shown by E. In addition, all regions of the CA1 pyramidal cell are synaptically stimulated because we assume that electric field not only depolarises the postsynaptic neuron but also elicits spikes in presynaptic neurons. (b): Elimination of LTP when dendritic sodium channels are suppressed, simulating TTX application. (c): Elimination of LTP when NMDAR (NMDA receptor)-like processes within the synaptic model are disabled in silico. (d): Large reduction in LTP induction (as compared to control, i.e. no perturbation condition) when L-type voltage-gated calcium channels are suppressed in silico. (e): Elimination of LTP observed when calcium-free solution is modelled.