Strong association between genomic 3D structure and CRISPR cleavage efficiency
Fig 2
3D features perform comparably to state-of-the-art features and encode new information.
(A) Boxplots of Pearson correlations (absolute values) between predictive features and CRISPR efficiency in the Leenay, TTISS and GUIDE-Seq datasets. Blue: 420 sequence features; orange: 5 thermodynamic features; green: 9 3D features. (B-C) Bar charts of Pearson correlations (blue) and partial correlations (orange) with CRISPR efficiency, in the Leenay, TTISS and GUIDE-Seq datasets. The partial correlation of each vector controls for all other vectors in the dataset’s subplot. (B) Epigenetic features and 3D feature (correlations appear in absolute value); (C) State-of-the-art models and 3D feature.