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Structural and practical identifiability of contrast transport models for DCE-MRI
Fig 4
Ktrans practical identifiability for LTK model and Type I enhancement curve.
Top row: profile likelihood and confidence levels at 68%, 80%, and 95% for the parameter Ktrans in the (AA), (RA), and (RR) case for the Type I enhancement curve. Inset in the first subplot shows a zoom of the region around the best-fitted value 
(red marker). Bottom row: compensating profiles of the parameters ve, vp, and λ with respect to variation of Ktrans around its best-fitted value. Variation of ±50% around the optimal value of Ktrans are considered. Two colors are for two different y-axis: black curves refer the left y-axis and red curves to the right y-axis. Different line styles are used to distinguish curves referring to the same y-axis. For each curve, the name of the corresponding parameter is indicated above the line in the same color.
doi: https://doi.org/10.1371/journal.pcbi.1012106.g004