Spatial and temporal correlations in human cortex are inherently linked and predicted by functional hierarchy, vigilance state as well as antiepileptic drug load
Fig 2
Spatial and temporal correlations (SC, TC) are tightly linked, decline under AED action and break down during slow-wave sleep (SWS).
A, B Timeseries of TC and SC over one day for high and low AED dosages for one exemplary patient. SWS is marked with green squares and seizures (grey bars) are excluded from the analysis. C Co-variation of SC and TC shown for one patient. The black line indicates a logarithmic fit. D Surrogate data of SC and TC are overall smaller and exhibit no co-dependence. E, F Autocorrelation and cross-correlation functions averaged over all patients exhibit a faster decline during high AED load days. The grey shaded area in F was used for the SC calculation. G, H Reduction of TC and SC during SWS and high AED load (Wilcoxon signed rank test). Single patient values are indicated as thin lines, the median is given as dashed line and whiskers extend to the 95% confidence interval calculated via bootstrapping. Surrogate data (grey bars) exhibit no difference.