Modeling the progression of Type 2 diabetes with underlying obesity
Fig 7
Dynamics of glucose, insulin and functional beta-cell mass level for patient B with mild obesity (X approaches 0.17 progressively).
In this case, the factor X can only increase the glucose level to 104.8 mg/dl and the elevation is counteracted afterward by an upsurge of insulin. The insulin level remains moderately high after day 11010, driven by the continual hyperresponsiveness of beta-cells to the pathogenic risk. At the end, the glucose concentration of patient B can stay stable at a euglycemic level with 96.8 mg/dl.