Network models of protein phosphorylation, acetylation, and ubiquitination connect metabolic and cell signaling pathways in lung cancer
Fig 3
EGFR signaling and small molecule transport pathway interactions.
(A) Combined CFN/CCCN showing composite shortest paths from the Bioplanet pathways EGF/EGFR signaling pathway (top row) and Transmembrane transport of small molecules (bottom row). PTM clusters are apparent as cliques connected by yellow correlation edges. (B) same as A but showing CFN edges only. (C) “Mutual friends” (center row) defined as proteins that connect to at least one member of each pathway in the CFN. (D) CFN interactions between RTKs, SFKs and the Transmembrane transport of small molecules pathway. (E) Direct CFN interactions between members of the EGF/EGFR signaling and Transmembrane transport of small molecules pathways. PTMs that were significantly changed (>2.25-fold) in response to erlotinib are shown. Node size and color represents the median log2 fold change in response to erlotinib (A, B, C, E), or dasatinib (D); color scale bar shown in C. Node border and shape and edge colors are defined in S2C Fig.