Deriving time-concordant event cascades from gene expression data: A case study for Drug-Induced Liver Injury (DILI)
Fig 9
Transcription Factor (TF) activity and expression before adverse histopathology.
A) Significance of enrichment in adverse conditions for matched TF activity and expression-based events. Events only found on the expression or TF level are not included in the figure due to the inability to perform a statistical test for those. B) For significantly enriched TF activity-based events, the True Positive Rate (TPR) of observing TF activity before or at the time of adverse histopathology is shown, as well as the TPR for observing TF expression changes before TF activity in the time series where it precedes adverse histopathology.