Deriving time-concordant event cascades from gene expression data: A case study for Drug-Induced Liver Injury (DILI)
Fig 2
Workflow to quantify time concordance between preceding gene expression-derived events and later adverse histopathology.
First, events are derived from the gene expression and histopathology data. Pathway and TF activity is inferred based on the expression of the respective gene sets using GSVA [26] and binary histopathology labels are derived from the continuous toxscores. Secondly, we derive the first activation of expression-based events as well as of adverse histopathology. Lastly, we quantify the time concordance between potential preceding events (PE) which are derived from gene expression and adverse histopathology as potential later event (LE).