Dissecting mutational allosteric effects in alkaline phosphatases associated with different Hypophosphatasia phenotypes: An integrative computational investigation
Fig 10
Performance evaluation of feature classification.
(A) Heatmap of pairwise Spearman’s rank correlation coefficients between different features. (B) Feature importance of all used features ranked based on mean decrease accuracy in the RF classification. ROC curve AUCs for 14 features as a function of 1-specificity, including ROC curves for evaluating each feature in classifying ALPL mutations between (C) the control and severe groups, (D) control and mild groups, and (E) mild and severe groups.