Base-resolution prediction of transcription factor binding signals by a deep learning framework
Fig 7
FCNsignal successfully pinpoints causal disease-related SNPs from LD groups.
(A) The SNP scores of FCNsignal (top) and DeltaSVM (bottom) on the myeloma, pan-autoimmune, and CLL. The risk variants for the myeloma, pan-autoimmune, and CLL are rs4487645, rs6927172, and rs539846 respectively. (B) The distribution of the SNP scores of cancer breast predicted by FCNsignal (left) and DeltaSVM (right). The SNP scores of LD groups predicted by FCNsignal are more concentrated in the low score region than the ones predicted by DeltaSVM.