Base-resolution prediction of transcription factor binding signals by a deep learning framework
Fig 6
The enrichment of different TFBSs in the six cell lines.
(A) The heat maps of diverse motifs in the six cell lines. CTCF binding motif is enriched in all six cell lines. EVT6, NR2C2, TFAP2A, and TEAD1 binding motifs are enriched in the GM12878, HepG2, MCF7, and IMR90 respectively. (B) The intersection ratio between the above five TFs ChIP-seq peaks and the ATAC-seq peaks of the six cell lines. The intersection ratio of CTCF to the six cell lines is all very high (mean: 0.786) corresponding to the observation that CTCF binding motif is enriched in all six cell lines. The maximum intersection ratio of the other four TFs is 0.319, 0.458, 0.22, and 0.573, corresponding to the GM12878, HepG2, MCF7, and IMR90 cell lines respectively.