Base-resolution prediction of transcription factor binding signals by a deep learning framework
Fig 4
The performance of FCNsignal in locating TF-DNA binding regions.
(A) The results of FCNsignal in locating potential binding regions for CTCF and YY1 on the whole chromosome 17 as well as the distribution of h3k27ac signals in the supported and unsupported sequences, where ‘Supported’ means existing in the real peaks and ‘Unsupported’ means the opposite. (B) The number of motif instances found by FIMO on the located regions and the negative regions as well as the distribution of the matched–log2(p-value) values. (C) The motif enrichment analysis on the located regions and the negative regions. The dash lines represent the results on the negative regions. (D) The base-resolution signals of DNA sequences of arbitrary length predicted by FCNsignal, the true signals, and the h3k27ac signals. The range of the top DNA sequence is chr17: 8376183–8384180 (7997bp length), and the range of the bottom DNA sequence is chr17: 41548466–41580329 (31863bp length).