Modeling cortical synaptic effects of anesthesia and their cholinergic reversal
Fig 7
Effects of anesthetic concentration and ACh induced reversal on similarity between cellular functional connectivity.
Cosine similarity Z-Score was computed for every pairwise functional connection between neurons. A) Experimental functional connectivity was computed between the highest firing neuron for each electrode with similarity computed across different levels of anesthesia. B,C) Functional network similarity computed for simulated anesthesia and reversal. Z-Scores were computed comparing the Network similarity to mean and standard deviation of similarities for distributions randomly jittered +/- 5 milliseconds. Each is averaged over ten runs.