Modeling cortical synaptic effects of anesthesia and their cholinergic reversal
Fig 5
Characterization of anesthetic effects on network connectivity and their simulated ACh reversal.
Measures of network connectivity computed from experimental data and optimized model networks as a function of anesthetic concentration and simulated reversal level: A) network excitatory connectivity strength, B) network inhibitory connectivity strength, C) network excitatory connectivity probability, D) network inhibitory connectivity probability. A1-AR4/B1-BR4 (x-axis) denote simulated anesthetic concentration levels and reversal states obtained in optimized networks with corresponding parameters listed in Table 2. Blue line (with corresponding axis labels on the top) denotes measures computed from experimental data, black (pink) line denotes measures computed from A-series (B-series) network simulations. In these measures, the presence of a significant connection was determined through cross correlogram analysis as described in Methods section. Stars denote significance between initial anesthetic/reversal and subsequent simulations. Error bars of +/- SEM based on 10 network realizations for best fit optimization.