Modeling cortical synaptic effects of anesthesia and their cholinergic reversal
Fig 2
Changes in anesthesia level lead to transitions from high frequency asynchronous to low frequency synchronous spiking patterns.
A). Raster plots of experimentally recorded neuronal activity in response to changes in desflurane levels. For higher concentrations of desflurane (6%), oscillatory synchronous network activity can be seen in spiking dynamics. For lower levels of anesthetic, oscillations are not apparent and asynchronous activity dominates. B) Raster plots for simulated anesthetic effects in optimized model networks for constant gKs (A-Series) and the simulated ACh-induced reversal of anesthetic effects (A-Series reversal). C) Raster plots for simulated anesthetic effects in optimized networks with changing gKs (B-Series) and its reversal (B Series reversal). In both B) and C), simulated anesthetic reversal shows reinstatement of asynchronous from synchronous spiking patterns. Simulation results based on best fit parameters (lowest cost optimization when averaged across anesthesia levels).