Approximate distance correlation for selecting highly interrelated genes across datasets
Fig 5
Highly interrelated genes selected by ADC between different cell types along the hematopoietic cell lineage.
(A) A schematic of mouse hematopoietic differentiation. The cells in gray color cell type were not present in our datasets. (B) Heat map shows the number of highly interrelated genes selected by ADC cross six cell types (FDR = 0.10). The upper triangular is the result of mouse hematopoietic cells while the lower triangular is the result of human hematopoietic cell data downloaded from GEO with accession code GSE117498. Unsupervised hierarchical clustering analysis was performed with the reciprocal value of the number. (C) Confusion matrix of data-driven clusters representing the percent frequency distribution of immunophenotypically defined cell types. (D) Heat map shows the dissimilarity of the distributions of the three cell types using the Jensen-Shannon (JS) divergence.